The combination of restricting carbohydrate and total calorie intake may augment the beneficial effects of reducing BMI, body weight, and metabolic risk factors among overweight/obese individuals. The reduction of carbohydrate intake without restricting caloric intake is more potent to achieve weight loss over 12 weeks when compared to a calorie-restricted diet in overweight/obese adults. Plasma glucose, homeostasis model assessment of insulin resistance, and cholesterol concentrations (total, LDL, and HDL) did not change significantly between the groups during the 12-week intervention. Serum triglycerides were significantly reduced in the LC + CR diet group compared with the LC or CR diet alone. Furthermore, compared with the CR diet, the LC + CR diet and LC diet further reduced body weight, waist circumference, and body fat. LC + CR diet was more effective than LC or CR diet alone at reducing BMI ( P = 0.001 and P < 0.001, respectively). ResultsĪ total of 298 participants were analyzed. All participants attended health education sessions during the trial. The secondary outcomes included body weight, waist circumference, waist-to-hip ratio, body fat, and metabolic risk factors. The primary outcome was the change in body mass index (BMI). MethodsĪ total of 302 participants were randomized to LC diet ( n = 76), CR diet ( n = 75), LC + CR diet ( n = 76), or normal control (NC) diet ( n = 75) using a computer-based random number generator. We conducted a 12-week randomized trial to compare the effects of these diets separately and in combination on both weight loss and metabolic risk factors in overweight/obese individuals. However, the two regimens have yet to be thoroughly compared. Both low‐carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits.
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